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Home / IAS Preparation / National Biopharma Mission

National Biopharma Mission - Learn about Innovate in India i3 Programme, Its Objectives & Incubators!

Last Updated on Sep 06, 2023
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The National Biopharma Mission (NBM) is a joint mission between the government and industry to accelerate the development of biopharmaceuticals in India. The mission was launched in 2017. The task is focused on four areas: vaccine development, biosimilars, medical devices, and diagnostics. The mission aims to make India a global leader in biopharmaceuticals by 2030. The mission has already made significant progress, with several new biopharmaceutical products in development. The mission is expected to majorly impact the Indian healthcare system, making it more affordable and accessible to all. The Innovate in India (i3) program is a collaborative initiative between the Department of Biotechnology (DBT), the World Bank, and the Biotechnology Industry Research Assistance Council (BIRAC).

This topic of “National Biopharma Mission” is important from the perspective of the UPSC IAS Examination, which falls under General Studies Paper 3 (Mains) and General Studies Paper 1 (Preliminary) and particularly in the Science and Technology section of the UPSC Exam. This article will discuss the ‘National Biopharma Mission’ and learn about NBM Mission or Innovate in India i3 Programme, Its Objectives, Incubators, and, & More!

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Dr Jitendra Singh, Union Minister of State for Earth Sciences and Science and Technology, stated that the bioeconomy will be critical to India’s future economy over the next 25 years.

The Union Minister stated in July 2022, when releasing India’s Bioeconomy Report 2022 that India’s Bioeconomy will reach $300 billion US dollars by 2030, up from 80 billion US dollars in 2021.

Supporting 101 pan-India projects in the Biopharma sector has led to a growth in employment opportunities. These projects have employed 1,065 individuals, with 304 of them being scientists or researchers. Additionally, the mission is actively contributing to the enhancement of human capital by offering specialized training programs designed to address crucial skill gaps, particularly aimed at strengthening product development.

What is the National Biopharma Mission?

The National Biopharma Mission is an industry-academia cooperation mission. It is led by the Department of Biotechnology (DBT) in collaboration with the World Bank to accelerate biopharmaceutical discovery research and early development. The NBM Programme is a Pan-India Program. It aims to make India a hub for the design and development of novel, cost-effective biopharmaceutical products and solutions. The NBM Programme was established to carry out the National Biotechnology Development Strategy commitments made by DBT and to support other significant national missions like “Make in India” and “Start-up India.” The Union government approved the National Biopharma Mission for a total implementation cost of $250 million. The World Bank providing 50% of the funds as loan assistance. Under the NBM Programme, the Innovate in India (i3) Programme aims to create an enabling ecosystem to promote entrepreneurship and indigenous manufacturing in the biopharma sector.

Launch

The Union Ministry of Science and Technology launched the National Biopharma Mission under the Department of Science and Technology in June 2017.

Controlling Ministry

The NBM Programme or Innovate in India (I3) Programme is controlled by the Biotechnology Industry Research Assistance Council (BIRAC) under the Department of Biotechnology, Ministry of Science and Technology, Government of India.

The Vision of the National Biopharma Mission

The vision of the National Biopharma Mission is to facilitate and nurture an ecosystem to advance India’s pharmaceutical technological and product development capabilities to an internationally competitive level over the next decade, as well as to transform the health standards of the Indian population.

About Bio-Pharmaceuticals

Biopharmaceuticals are complex medicines derived from living cells or organisms and are frequently created using cutting-edge biotechnological techniques. Currently, a wide range of biopharmaceuticals is used as therapeutic agents, such as vaccines, whole blood (or blood components), hormones, cytokines, cell therapies, gene therapies, enzymes, allergenic, monoclonal antibodies, immunosera, antigens, tissues, and items made from recombinant DNA. Human insulin was the first recombinant biopharmaceutical approved for treating diabetes in the United States in 1982.

Check the Article Active Pharmaceutical Ingredients here!

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Objectives of the National Biopharma Mission

The NBM Programme has been authorized to pursue the following objectives:

  • To develop biopharma products from leads at an advanced stage of the product development lifecycle.
  • To develop biopharma products such as vaccines, biotherapeutics, medical devices, and diagnostics.
  • To create a favourable environment for India’s technological and product development capabilities in biopharmaceuticals.
  • To establish and strengthen shared necessary infrastructure for product validation and development.
  • To develop human capital by providing targeted training to address critical skill gaps throughout the product development supply chain.
  • To develop and improve technology transfer and intellectual property management capacity and capabilities.

Innovate in India i3 Programme.

The Innovate in India (i3) program is a government initiative within the NBM Programme, aimed at fostering entrepreneurship and domestic biopharmaceutical production through collaboration between academia and industry. BIRAC, the Biotechnology Industry Research Assistance Council, is responsible for implementing the i3 program, and it is open to all biopharmaceutical entrepreneurs.

This program aims to establish enduring partnerships between industry and academia, bolstering the entrepreneurial ecosystem. Innovate in India (i3) will have a specific focus on the production of new vaccines, bio-therapeutics, diagnostics, and medical devices to address the increasing disease burden in India.

Additionally, it seeks to connect previously isolated centers of excellence, enhance regional capabilities, and expand the existing bio-cluster network in terms of capacity, quantity, and output quality.

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Major activities of the National Biopharma Mission

The major activities under the NBM Programme are as follows:

  • Specific Product Development
  • Building Shared Infrastructure
  • Building & strengthening domain-specific knowledge and management skills

Specific Product Development

Under the category of “Specific product development,” three products are being created, namely:

  • Vaccines: The vaccine component of the NBM Programme is focused on accelerating vaccine development for complex, emerging, and high-priority infections in India, such as Covid-19, BCG, Flue, dengue Chikangunia, and others.
  • Biotherapeutics: The Biotherapeutics component of the NBM Programme is focused on developing biosimilar products (therapeutic proteins and monoclonal antibodies) such as novel cell lines, biosimilar clones, and biosimilars at various stages of development.
  • Medical devices and diagnostics: The medical devices and diagnostics component of the NBM Programme is focused on developing core technologies that provide accessible domestic alternatives to the market’s current foreign brands.

Building Shared Infrastructure

The NBM Programme is actively working to establish an environment allowing India to develop products at a reasonable cost. The following facilities are supported by building shared infrastructure:

  • Good Laboratory Practice (GLP): Compliant facility for biotherapeutics analytical characterization.
  • Good Clinical Laboratory Practices (GCLP) facilities for clinical immunogenicity.
  • Good Manufacturing Practices (GMP): Manufacturing facilities for biotherapeutics (microbial and mammalian).
  • Manufacturing of lentiviruses for cell therapy.
  • Rapid prototyping facilities for medical devices and diagnostics.
  • Electrical safety testing of electronic medical devices using EMI and EMC facilities.
  • A large animal facility for implantable medical device testing.

Building & strengthening domain-specific knowledge and management skills

The following initiatives are aimed at developing and strengthening domain-specific knowledge and management skills:

  • The NBM Programme supports training and workshops as part of its mandate.
  • The workshops covered clinical research, regulatory compliance, technology transfer, biopharmaceuticals, and medical devices.
  • Additionally, Several more workshops are planned as part of the National Biopharma Mission.
  • The NBM Programme supported the training, with an estimated 37.12% of the participants being female.
  • Approximately 644 candidates have been trained thus far, with 46.89% female representation in 2020-21.

About DRIVEN

The NBM Programme also prioritizes developing a data management system for better data analysis and reporting and increasing clinical trial capacity for testing biologicals and vaccines under DBT’s Resource of Indian Vaccine Network (DRIVEN).

Focus Verticals of National Biopharma Mission

The scientifically driven enterprise aims to create an ecosystem for low-cost product development and is focused on the four verticals listed below:

  • The NBM Programme will concentrate on the development of new vaccines, bio-therapeutics, diagnostics, and medical devices to address the country’s rising disease burden.
  • Creating technology transfer offices to improve industry-academia connections.
  • Developing human capital by providing specific training programs.
  • To create a shared infrastructure and facilities such as GLP validation and a research lab.

Study the Article Maternal and Neonatal Tetanus here!

Achievements of NBM

The NBM programme of the Department of Biotechnology supported the Phase III trials of ZyCoV-D, a DNA vaccine developed by ZydusCadila.

Some major initiatives supported by the NBM Program include:

  • The Serum Institute of India is conducting a phase 3 trial of the rBCG vaccine.
  • Bharat Biotech’s inactivated rabies virus vector vaccine.
  • Gennova Biopharmaceuticals Ltd.’s mRNA vaccine.
  • AurobindoPharma’s VesiculoVax platform-based candidate.

National Biopharma Mission UPSC Facts And Figures

Here are some key facts and figures about the National Biopharma Mission for the UPSC Exam:

National Biopharma Mission (NBM)

National Biopharma Mission approved in

May 2017.

National Biopharma Mission approved by

Cabinet Committee on Economic Affairs (CCEA).

National Biopharma Mission launched in

June 2017.

National Biopharma Mission launched by

Ministry of Science and Technology.

National Biopharma Mission implemented by

Biotechnology Industry Research Assistance Council (BIRAC).

National Biopharma Mission implemented cost

US $ 250 million.

National Biopharma Mission funded by

World Bank (50% of the funds as loan assistance).

National Biopharma Mission’s key target

Indian biotechnology industry is to reach $100 billion by 2025.

UPSC Previous Year Questions

Q1. What is the basic principle behind vaccine development? How do vaccines work? What approaches were adopted by the Indian vaccine manufacturers to produce COVID-19 vaccines? (UPSC Mains 2022, GS Paper 3)

Q2. What are the research and developmental achievements in applied biotechnology? How will these achievements help to uplift the poorer sections of society? (UPSC Mains 2021, GS Paper 3).

Conclusion

The National Biopharma Mission is expected to strengthen academic researchers’ translational capabilities while also empowering bio-entrepreneurs and small and medium-sized businesses. The World Bank’s global experience would be invaluable in establishing long-term global links, technical assistance, and knowledge exchange between public and private partners for the advancement of biotech businesses.

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National Biopharma Mission FAQs

The Union Ministry of Science and Technology, Government of India, launched the National Biopharma Mission in June 2017.

The National Biopharma Mission (NBM) aims to accelerate biopharmaceutical research and development in India.

India's economy is now worth US$ 80.12 billion as of 2021, up from US$ 70.2 billion in 2020 by a whopping 14.13%.

The Innovate in India (i3) program is an academia-industry partnership program that is part of the National Biopharma Mission to promote entrepreneurship and domestic biopharmaceutical production.

The National Biopharma Mission's target is to build a $100 billion biotech industry by 2025 and take 5% of the global biopharmaceutical market.
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