Which of the following is used as an immuno suppressor for kidney transplantation?

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UKPSC Combined Upper PCS (Prelims) Exam (General Studies) Official Paper-I (Held On: 14 Jul, 2024)
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  1. Antibiotics
  2. Vaccines
  3. Interferon
  4. Monoclonal antibodies

Answer (Detailed Solution Below)

Option 4 : Monoclonal antibodies
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The correct answer is option 4.

Key Points

  • Monoclonal antibodies are used as immunosuppressive agents during organ transplantation, including kidney transplants, to prevent rejection by the recipient’s immune system. Hence, option 4 is correct.
  • They specifically target immune cells (like T-lymphocytes) that might attack the transplanted organ.
  • Examples include:
    • Basiliximab (anti-IL-2 receptor)
    • Muromonab-CD3 (OKT3)
  • Why Not Others?
    • Antibiotics: Used to fight infections, not for immunosuppression.
    • Vaccines: Stimulate the immune system, opposite of suppression.
    • Interferon: Boosts immune responses, used in viral infections and cancers, not for transplant rejection.
  • Thus, monoclonal antibodies are the preferred immunosuppressive agents in transplant therapy.
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