Which one of the following is not present in the filtration slit diaphragm?

The correct answer is Option 2 i.e. Paxillin.

Concept:​

• The slit-diaphragm, a cell-cell connection between the foot processes of renal podocytes, controls the kidney's ability to filter blood,
• It is essential for mammalian survival.
• It is believed that the slit diaphragm serves as the kidney's last line of defence or a molecular sensor of renal filtration.

​Explanation:

• A considered specialised adherens junctions, slit diaphragms include both distinctive membrane proteins such as nephrin, podocin, and Neph1 and common adherens junction proteins e.g., P-cadherin, FAT, and catenins.
• NEPH2 belongs to the NEPH family of proteins, which are highly conserved within mammalian and submammalian species.
• NEPH2 has been shown to interact with cytoplasmatic proteins of the slit diaphragm.

Important Points

Option 1: NEPH1

• Consider the explanation above thus this option is true, as NEPH1 belongs to membrane proteins of slit diaphragms.

Option 2: Paxillin

• Consider the explanation above thus this option is not true.

Option 3: Nephrin

• Consider the explanation above thus this option is true, as Nephrin belongs to membrane proteins of slit diaphragms.

Option 4: NEPH2

• Consider the explanation above thus this option is true, as NEPH2 has been shown to interact with cytoplasmatic proteins of the slit diaphragm.