Transgenic mammal 'Polly' produced _________ in her milk representing major advance in Pharming.

The correct answer is option 2

Key PointsTransgenic mammal 'Polly' produced human factor IX in her milk, representing a major advance in Pharming. Pharming refers to the production of pharmaceuticals using genetically modified animals or plants. In this case, 'Polly' was genetically engineered to express human factor IX in her milk.

Human factor IX

• is a blood clotting factor that is crucial for the normal process of blood clot formation.
• People with hemophilia B, a genetic disorder, lack or have low levels of factor IX, which can lead to excessive bleeding.
• By producing human factor IX in the milk of transgenic animals like 'Polly', scientists aimed to create a sustainable and potentially more cost-effective source of this important protein for treating hemophilia B patients.

This breakthrough in Pharming offered the potential to produce therapeutic proteins in large quantities through the milk of transgenic animals, providing a new approach to addressing medical needs.Hence option 2 is correct.